RENAL TUBULAR NECROSIS IN RATS TREATED WITH DIETHYLENE GLYCOL
نویسندگان
چکیده
منابع مشابه
Reproductive toxicology. Diethylene glycol.
Background: Human linkage and animal QTL studies have indicated the contribution of genes on Chr17 into blood pressure regulation. One candidate gene is PNMT, coding for phenylethanolamine-N-methyltransferase, catalyzing the synthesis of epinephrine from norepinephrine. Methods: Fine-scale variation of PNMT was screened by resequencing hypertensive (n = 50) and normotensive (n = 50) individuals...
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During toxicologic evaluation of a dimeric PEG-linked protein, tumor necrosis factor binding protein (TNF-bp), vacuolation of renal cortical tubular epithelium was seen in male and female Sprague-Dawley rats (200-300 g) given i.v. doses of 40, 20, or 10 mg/kg every other day for 3 months. Tubular lesions in rats treated with 20 or 40 mg/kg for 3 months were only partially reversible after a 2-m...
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The aim of the present study was to investigate the hepatotoxic effects of accidental intravenous diethylene glycol (DEG) poisoning in patients with liver disease. Clinical manifestations were recorded and liver function tests were carried out for 64 patients with liver disease who had been accidentally treated intravenously with DEG. Comparisons were made between the poisoned and non-poisoned ...
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Dear Editor, We previously reported a case of delayed autonomic neuropathy in a patient with diethylene glycol (DEG) poisoning, and would like to emphasize two characteristic complications, sensorimotor neuropathy and renal failure, occurring in the same case, because of their severity and possible reversibility. Although once recovered from acute symptoms by day 3, the patient suffered from lo...
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OBJECTIVE To discover the cause of acute renal failure in 36 children aged 2 months to 6 years who were admitted to two hospitals in Delhi between 1 April and 9 June 1998. METHODS Data were collected from hospital records, parents and doctors of the patients, and district health officials. Further information was obtained from house visits and community surveys; blood and stool samples were c...
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ژورنال
عنوان ژورنال: Journal of Toxicologic Pathology
سال: 1989
ISSN: 0914-9198,1881-915X
DOI: 10.1293/tox.2.63